I will give an update after having tried Vice City and San Andreas. Thanks again @GhettoJesus ! Update: San Andreas and Vice City are both working, with Silent's ASI loader and SilentPatch, San Andreas will run and with ddraw and SilentPatch for Vice City it will run as well!

↑ SafeDisc retail DRM does not work on Windows 10 or Windows 11 and is disabled by default on Windows Vista, Windows 7, Windows 8, and Windows 8.1 when the KB3086255 update is installed. ↑ Applications writing to HKEY_LOCAL_MACHINE\SOFTWARE will be redirected to other locations based on various criterias, see the glossary page for more details.

Here is how it works: Boot up the game. Open Windows Task Manager. Right-click the game. Select the "Go to details" menu. Right-click gta-vc.exe (erroneously called Vice City.exe by Rockstar Support). Select the "Set affinity" option. Uncheck All Processors. Only leave the box near CPU 1 checked and .
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    • gta vice city mouse not working windows 11